With arrows, the amount of poison (and its deadliness) will be limited by the surface space of the point that is prepared. So with arrows, a poison strength of no more than vex is possible.
Once a weapon is coated, it is very easy for the wielder to error in its use and be poisoned by drawing the blade against themselves. This will happen any time that a 1 or a 2 has been rolled on the attack die, whereupon the user of the weapon must make save versus the poison. Assassins can used a coated weapon safely without needing to make save whatever the attack roll, as they have been trained to fight so as not to touch the blade.
See Attacking in Combat
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